Affordable Access

Publisher Website

Processing of the precursor to the major core polypeptide of adenovirus type 5 removes a region near the amino terminus

Authors
Journal
Virology
0042-6822
Publisher
Elsevier
Publication Date
Volume
82
Issue
2
Identifiers
DOI: 10.1016/0042-6822(77)90023-x

Abstract

Abstract The precursor to the major core polypeptide (pVII) of adenovirus type 5 has five methionine-containing tryptic peptides, while the mature core polypeptide (VII) after processing has only four. A technique utilizing the drug pactamycin has been used to determine the relative order (N terminal to C terminal) of the tryptic peptides within polypeptide pVII. Taking the order of these peptides into account and correlating it with the peptide missing from polypeptide VII, we are able to conclude that a region near the amino terminus of polypeptide pVII is removed during proteolytic processing.

There are no comments yet on this publication. Be the first to share your thoughts.