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A highly efficient synthesis of22-deoxy-OSW-1by utilizing the intact skeleton of diosgenin

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
47
Issue
19
Identifiers
DOI: 10.1016/j.tetlet.2006.03.065

Abstract

Abstract 22-Deoxy-OSW-1 ( 1 ), an analogue of OSW-1 with the potent anticancer activity, was synthesized by utilizing the intact skeleton of diosgenin in 11 steps in 13.7% overall yield. This synthesis demonstrated an effective and reasonable synthetic strategy for bioactive steroids with side chains.

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