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Splenic macrophages during pregnancy in the mouse

Authors
Journal
Developmental & Comparative Immunology
0145-305X
Publisher
Elsevier
Publication Date
Volume
8
Issue
2
Identifiers
DOI: 10.1016/0145-305x(84)90051-x
Keywords
  • Mammals

Abstract

Abstract Pregnant CBA/Ca mice at mid-gestation showed a two-fold increase in the relative content of splenic macrophages, a change which was suggested to be due to enhanced migration. The proportion of spleen cells carrying a high density of Fc-receptors (assayed by EA-rosetting) was similarily increased in pregnant mice. The splenic content of non-lymphoid strongly esterase-positive cells was dramatically elevated at mid-gestation, but this increase was shown basically to be due to elevated numbers of esterase-staining erythroid blast cells. The pattern of the increase of Ig-secreting spleen cells was compared with that of macrophages and erythroid blast cells, and possible unspecific interaction at tissue-level is discussed.

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