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Increased frequency of micronucleated kidney cells in rats exposed to halogenated anaesthetics

Authors
Journal
Mutation Research/Genetic Toxicology and Environmental Mutagenesis
1383-5718
Publisher
Elsevier
Publication Date
Volume
413
Issue
1
Identifiers
DOI: 10.1016/s1383-5718(97)00187-3
Keywords
  • Rat Kidney Cell
  • Micronucleus Assay
  • In Vivo
  • Halothane
  • Enflurane
  • Isoflurane
  • Sevoflurane
  • Chloroform
  • Trichloroethylene
Disciplines
  • Design
  • Philosophy

Abstract

Abstract Six halogenated anaesthetics were tested for their ability to induce micronuclei formation in the rat kidney. A statistically significant increase in the frequency of micronucleated cells was detected in rats given a single p.o. dose of 4 mmol/kg of halothane (3.48×baseline), chloroform (3.32×baseline), trichloroethylene (3.24×baseline), sevoflurane (2.98×baseline), and isoflurane (2.95×baseline). In contrast, the response was substantially negative in rats given the same dose of enflurane. As compared to controls, rats treated with halothane and trichloroethylene displayed a reduction in the frequency of binucleated cells presumably due to a toxicity-induced inhibition of cellular proliferation. These findings suggest a potential genotoxic activity of halogenated anaesthetics for the rat kidney.

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