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Cdk1 Phosphorylation of the Dam1 Complex Strengthens Kinetochore-Microtubule Attachments

Authors
  • Gutierrez, Abraham1, 2
  • Kim, Jae ook3
  • Umbreit, Neil T.3
  • Asbury, Charles L.4
  • Davis, Trisha N.3
  • Miller, Matthew P.1
  • Biggins, Sue1
  • 1 Howard Hughes Medical Institute, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
  • 2 Molecular and Cellular Biology Program, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
  • 3 Department of Biochemistry, University of Washington, 1705 NE Pacific Street, Seattle, WA 98195, USA
  • 4 Department of Physiology and Biophysics, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
Type
Published Article
Journal
Current Biology
Publisher
The Author(s). Published by Elsevier Inc.
Publication Date
Sep 17, 2020
Identifiers
DOI: 10.1016/j.cub.2020.08.054
PMID: 32946748
PMCID: PMC7497780
Source
PubMed Central
Keywords
License
Unknown

Abstract

Chromosome segregation requires attachments between kinetochores and microtubules. In budding yeast, the kinetochore complex Dam1 oligomerizes around microtubules to facilitate this connection. Gutierrez et al. show that the cell-cycle kinase Cdk1 phosphorylates the Dam1 complex to strengthen kinetochore-microtubule attachments during mitosis.

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