Affordable Access

Publisher Website

d-Aspartate stimulation of testosterone synthesis in rat Leydig cells

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
444
Identifiers
DOI: 10.1016/s0014-5793(99)00045-9
Keywords
  • D-Aspartate
  • Testosterone
  • Steroidogenesis
  • Leydig Cell
  • Human Chorionic Gonadotropin
  • Glutamate Transporter

Abstract

Abstract d-Aspartate increases human chorionic gonadotropin-induced testosterone production in purified rat Leydig cells. l-Aspartate, d-, l-glutamate or d-, l-asparagine could not substitute for d-aspartate and this effect was independent of glutamate receptor activation. Testosterone production was enhanced only in cells cultured with d-aspartate for more than 3 h. The increased production of testosterone was well correlated with the amounts of d-aspartate incorporated into the Leydig cells, and l-cysteine sulfinic acid, an inhibitor of d-aspartate uptake, suppressed both testosterone production and intracellular d-aspartate levels. d-Aspartate therefore is presumably taken up into cells to increase steroidogenesis. Intracellular d-aspartate probably acts on cholesterol translocation into the inner mitochondrial membrane, the rate-limiting process in steroidogenesis.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

[Effect of annexin 5 on StAR and testosterone synt...

on Beijing da xue xue bao. Yi xue... Apr 18, 2011

[Ginkgo biloba extract enhances testosterone synth...

on Zhonghua nan ke xue = National... April 2008

Effects of cannabinoids on testosterone and protei...

on Molecular and Cellular Endocri... July 1979
More articles like this..