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Fecal Tests: From Blood to Molecular Markers

Authors
Journal
Current Colorectal Cancer Reports
1556-3790
Publisher
Springer-Verlag
Publication Date
Volume
7
Issue
1
Identifiers
DOI: 10.1007/s11888-010-0084-8
Source
Legacy
Keywords
  • Article
Disciplines
  • Biology
  • Chemistry

Abstract

Detection of molecular markers for colorectal neoplasia in feces has the potential to improve performance of simple noninvasive screening tests for colorectal cancer. Most research has explored the value of DNA-based, RNA-based, and protein-based markers. In all cases there has been a trend to move from a single marker to a panel of markers to improve sensitivity. Unfortunately, no type of molecular marker has proved specific for neoplasia. DNA tests have been improved by combining mutation detection with assessment of DNA integrity plus epigenetic markers of neoplasia. RNA-based approaches are just beginning to explore the full power of transcriptomics. So far, no protein-based fecal test has proved better than fecal immunochemical tests for hemoglobin. Finally, no marker or panel of markers has yet been developed to the point where it has been evaluated in large unbiased population studies to assess performance across all stages of neoplasia and in all practical environments.

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