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Positive correlation of plasma transforming growth factor-β1 levels with tumor vascularity in hepatocellular carcinoma

Authors
Journal
Cancer Letters
0304-3835
Publisher
Elsevier
Publication Date
Volume
89
Issue
1
Identifiers
DOI: 10.1016/0304-3835(95)90156-6
Keywords
  • Transforming Growth Factor-β1
  • Hepatocellular Carcinoma
  • Angiogenesis
  • Tumor Vascularity
Disciplines
  • Medicine

Abstract

Abstract Transforming growth factor-β1 (TGF-β1) has been implicated in tumor progression by promoting angiogenesis or suppressing immune system. We reported previously that transforming growth factor-β1 (TGF-β1) is overproduced by human hepatocellular carcinoma (HCC) tissues and that plasma TGF-β1 levels are elevated in patients with HCC. In the present study, we investigated the relationship between plasma TGF-β1 levels and tumor vascularity as assessed by conventional celiac angiography in 17 patients with HCC. The plasma TGF-β1 level did not correlate with tumor size or underlying liver disease. However, we found that plasma TGF-β1 levels correlated positively with the tumor vascularity. These results suggest that excessive TGF-β1 production may contribute to tumor angiogenesis in HCC.

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