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CD4 + T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features

Authors
  • Greenshields-Watson, Alexander1
  • Attaf, Meriem1
  • MacLachlan, Bruce J.1, 2
  • Whalley, Thomas1
  • Rius, Cristina1
  • Wall, Aaron1
  • Lloyd, Angharad1
  • Hughes, Hywel1
  • Strange, Kathryn E.1
  • Mason, Georgina H.1
  • Schauenburg, Andrea J.1
  • Hulin-Curtis, Sarah L.1
  • Geary, James1
  • Chen, Yuan1
  • Lauder, Sarah N.1
  • Smart, Kathryn1
  • Vijaykrishna, Dhanasekaran2
  • Grau, Miguel L.2
  • Shugay, Mikhail3
  • Andrews, Robert1
  • And 6 more
  • 1 Cardiff University, School of Medicine, Heath Park, Cardiff, UK
  • 2 Monash Biomedicine Discovery Institute, 19 Innovation Walk, Clayton, Victoria 3800, Australia
  • 3 Center of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russia
  • 4 Department of Gastroenterology, Hepatology and Endoscopy, University Hospital of Wales, Cardiff, UK
Type
Published Article
Journal
Cell Reports
Publisher
Elsevier
Publication Date
Jul 14, 2020
Volume
32
Issue
2
Identifiers
DOI: 10.1016/j.celrep.2020.107885
PMID: 32668259
PMCID: PMC7370177
Source
PubMed Central
Keywords
License
Unknown

Abstract

CD4+ T cells orchestrate protection from severe influenza. However, knowledge of epitopes and the molecular patterns associated with recognition across the population is lacking. Greenshields-Watson et al. identify several influenza epitopes from internal proteins and use them to explore the biochemical features that underpin CD4+ T cell responses to influenza.

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