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CD4+CD25high T cell numbers are enriched in the peripheral blood of patients with rheumatoid arthritis.

Authors
  • Han, Guang Ming
  • O'Neil-Andersen, Nancy J
  • Zurier, Robert B
  • Lawrence, David A
Type
Published Article
Journal
Cellular Immunology
Publisher
Elsevier
Publication Date
Jan 01, 2008
Volume
253
Issue
1-2
Pages
92–101
Identifiers
DOI: 10.1016/j.cellimm.2008.05.007
PMID: 18649874
Source
Medline
License
Unknown

Abstract

Accumulating evidences support that CD4(+)CD25(high) T regulatory (Treg) cells play an essential role in controlling and preventing autoimmunity. Paradoxically, RA patients have elevated numbers of circulating CD4(+)CD25(high) T cells, however, the inflammation is still ongoing. Further identification of these CD4(+)CD25(high) T cells may contribute to a better understanding of underlying mechanisms. We show here that these CD4(+)CD25(high) T cells were composed of CD4(+)CD25(high)FoxP3(+) Treg cells and activated CD4(+)CD25(high)FoxP3(-) effector cells. Moreover, there were significantly more Treg cells and effector T cells expressing GITR, and more monocytes expressing GITR-L. Thus, although RA patients have elevated numbers of CD4(+)CD25(high) T cells, the suppressive function is not increased, because of the increased number of activated effector T cells. In addition, the GITR-GITR-L system was activated in RA patients, which might lead to diminish suppressive activity of Treg cells and/or lead to resistance of activated effector T cells to suppression by Treg cells, thus, contributing to the ongoing inflammation in RA patients.

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