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CD4+CD25+ regulatory T cells inhibit immune-mediated transgene rejection.

Authors
  • Gross, David-Alexandre
  • Leboeuf, Marylene
  • Gjata, Bernard
  • Danos, Olivier
  • Davoust, Jean
Type
Published Article
Journal
Blood
Publication Date
Dec 15, 2003
Volume
102
Issue
13
Pages
4326–4328
Identifiers
PMID: 12893754
Source
Medline
License
Unknown

Abstract

Like cellular transplantation, gene therapy is often limited by immune rejection of the newly expressed antigen. In a model of gene transfer in muscle, delivery of the influenza hemagglutinin (HA) membrane protein by adeno-associated virus (AAV) is impaired by a strong immune response that leads to a rapid rejection of the transduced fibers. We show here that injection of HA-specific CD4+CD25+ T cells from T-cell receptor (TCR)-transgenic animals, concomitant with gene transfer, down-regulates the anti-HA cytotoxic and B-lymphocyte responses and enables persistent HA expression in muscle. This demonstrates for the first time that adoptive transfer of antigen-specific CD4+CD25+ regulatory T cells can be used to induce sustained transgene engraftment in solid tissues.

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