Affordable Access

CD4+ tumor-infiltrating lymphocytes in cervical cancer recognize HLA-DR-restricted peptides provided by human papillomavirus-E7.

Authors
  • Höhn, H
  • Pilch, H
  • Günzel, S
  • Neukirch, C
  • Hilmes, C
  • Kaufmann, A
  • Seliger, B
  • Maeurer, M J
Type
Published Article
Journal
Journal of immunology (Baltimore, Md. : 1950)
Publication Date
Nov 15, 1999
Volume
163
Issue
10
Pages
5715–5722
Identifiers
PMID: 10553103
Source
Medline
License
Unknown

Abstract

Human papillomavirus (HPV)-encoded proteins may provide targets for CD8+ or CD4+ T lymphocytes infiltrating into cervical cancer. We established an MHC class II-restricted CD4+ T cell line from a patient with cervical cancer that recognizes autologous (HPV35+, HPV59+) cervical cancer cells and the HLA-DR4-matched cervical cancer cell line Me180 (HPV68+) as determined by TNF-alpha secretion. Expression of different HPV-E7 genes in autologous B cells revealed that this T cell line defines a DR4-presented T cell epitope that is shared among the E7 genes of HPV59 and HPV68. MHC class II-presented peptides may be implemented to augment T cell responses directed against autologous tumor cells, particularly if cancer cells lack MHC class I expression, which is a frequent event in the evolution of cervical cancer.

Report this publication

Statistics

Seen <100 times