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Effect of the inhibition of dopamine uptake on the dopamine- and dimethyldopamine-induced-inhibition of the potassium-evoked release of [3H] acetylcholine from striatal slices

Authors
Journal
General Pharmacology The Vascular System
0306-3623
Publisher
Elsevier
Publication Date
Volume
20
Issue
6
Identifiers
DOI: 10.1016/0306-3623(89)90320-0

Abstract

Abstract 1. Dimethyldopamine was eight times more potent than dopamine in activating the D 2 receptor that inhibits the potassium-evoked release of [ 3H]acetylcholine from striatal slices. 2. Cocaine and mazindol produced an eight-fold shift in the concentration-response curve for dopamine, but not for dimethyldopamine. 3. The IC 50 of dimethyldopamine for the inhibition of [ 3H]dopamine uptake was thirty times greater than that for dopamine. 4. Dopamine may be less potent than dimethyldopamine at the D 2 receptor because dopamine has a higher affinity for the dopamine uptake system, resulting in its rapid removal from the vicinity of the receptor.

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