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Helicobacter pyloriinfection among offspring of patients with stomach cancer

Authors
Journal
Gastroenterology
0016-5085
Publisher
Elsevier
Publication Date
Volume
118
Issue
1
Identifiers
DOI: 10.1016/s0016-5085(00)70411-2
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Background & Aims: A positive family history is associated with an increased risk of stomach cancer. We compared the prevalence of Helicobacter pylori infection, a known risk factor for stomach cancer, between subjects with and without parental history of stomach cancer to evaluate a potential role of H. pylori infection in familial aggregation of stomach cancer. Methods: A total of 1351 men and women aged 30-74 years who participated in the German Health and Nutrition Survey conducted in the western part of Germany in 1987-1988 were included in the study. Detailed information on sociodemographic factors, nutritional factors, and parental history of cancer was obtained by standardized interviews. Serum samples were analyzed for immunoglobulin G antibodies against H. pylori by enzyme-linked immunosorbent assay. Results: The prevalence of H. pylori infection was much higher (69%) among subjects with a parental history of stomach cancer than among other subjects (44%). This association persisted after control for potential confounders by multiple logistic regression (adjusted odds ratio, 2.7;95% confidence interval, 1.3-5.9), and was particularly strong among subjects below age 55 (adjusted odds ratio, 5.1;95% confidence interval, 1.6-16.1). Conclusions: These results suggest that familial aggregation of stomach cancer may be explained at least partly by familial clustering of H. pylori infection. GASTROENTEROLOGY 2000;118:31-35

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