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CD26 and CD31 surface antigen expression on human colostral T cells.

Authors
  • Bertotto, A
  • Spinozzi, F
  • Gerli, R
  • Castellucci, G
  • Bassotti, G
  • Crupi, S
  • Fabietti, G M
  • Vagliasindi, C
  • Forenza, N
  • Pazzelli, P
Type
Published Article
Journal
Biology of the neonate
Publication Date
Jan 01, 1995
Volume
68
Issue
4
Pages
259–263
Identifiers
PMID: 8580217
Source
Medline
License
Unknown

Abstract

The expression levels of CD26 and CD31 surface antigens, two adhesion/activation molecules with helper and suppressor activities, respectively, were found to be significantly higher on human colostral T cells (CD3+) than in autologous peripheral blood samples. These findings provide further phenotypical evidence that immune system T lymphocytes are compartmentalized in the mammary gland late in pregnancy and during lactation. The question of whether these overexpanded T lymphocyte populations in breast milk modulate in situ, either by enhancing or suppressing, the cellular and/or humoral immune response of the suckling infant remains to be answered. Additional studies are, therefore, needed to explore this intriguing field concerning the immunology of the colostrum.

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