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CD154 expression triggered by purine analogues in vitro: Correlation with treatment response and autoimmune events in chronic lymphocytic leukemia.

Authors
  • Citores, Maria Jesus1
  • Castejon, Raquel
  • Villarreal, Mercedes
  • Rosado, Silvia
  • Garcia-Marco, Jose Antonio
  • Vargas, Juan Antonio
  • 1 Servicio de Medicina Interna, Hospital Universitario Puerta de Hierro Majadahonda, Universidad Autónoma de Madrid, Majadahonda, Madrid, Spain. [email protected] , (Spain)
Type
Published Article
Journal
Experimental hematology
Publication Date
March 2010
Volume
38
Issue
3
Pages
165–173
Identifiers
DOI: 10.1016/j.exphem.2009.12.001
PMID: 20026377
Source
Medline
License
Unknown

Abstract

Our preliminary results suggest that CD154 expression in CLL patients, which may be induced by purine analogues, is associated with resistance to fludarabine and with development of autoimmune manifestations.

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