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MiR-22 suppresses the proliferation and invasion of gastric cancer cells by inhibiting CD151.

Authors
  • Wang, Xun1
  • Yu, Honggang2
  • Lu, Xinyao3
  • Zhang, Peng3
  • Wang, Minglin3
  • Hu, Yikui4
  • 1 Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China. , (China)
  • 2 Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China. Electronic address: [email protected] , (China)
  • 3 Department of Gastroenterology, Wuchang Hospital of Wuhan City, Wuhan 430063, China. , (China)
  • 4 Department of Neurology, Pu Ai Hospital of Wuhan City, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430034, China. , (China)
Type
Published Article
Journal
Biochemical and Biophysical Research Communications
Publisher
Elsevier
Publication Date
Feb 28, 2014
Volume
445
Issue
1
Pages
175–179
Identifiers
DOI: 10.1016/j.bbrc.2014.01.160
PMID: 24495805
Source
Medline
Keywords
License
Unknown

Abstract

Gastric cancer (GC) is the second common cause of cancer-related death worldwide. microRNAs (miRNAs) play important roles in the carcinogenesis of GC. Here, we found that miR-22 was significantly decreased in GC tissue samples and cell lines. Ectopic overexpression of miR-22 remarkably suppressed cell proliferation and colony formation of GC cells. Moreover, overexpression of miR-22 significantly suppressed migration and invasion of GC cells. CD151 was found to be a target of miR-22. Furthermore, overexpression of CD151 significantly attenuated the tumor suppressive effect of miR-22. Taken together, miR-22 might suppress GC cells growth and motility partially by inhibiting CD151.

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