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miR-22 suppresses the proliferation and invasion of gastric cancer cells by inhibiting CD151

Authors
  • Wang, Xun
  • Yu, Honggang
  • Lu, Xinyao
  • Zhang, Peng
  • Wang, Minglin
  • Hu, Yikui1, 2, 1, 3, 4, 5, 6
  • 1 Department of Gastroenterology
  • 2 Renmin Hospital of Wuhan University
  • 3 Wuchang Hospital of Wuhan City
  • 4 Department of Neurology
  • 5 Pu Ai Hospital of Wuhan City
  • 6 Tongji Medical College of Huazhong University of Science and Technology
Type
Published Article
Journal
Biochemical and Biophysical Research Communications
Publication Date
Jan 01, 2014
Volume
445
Issue
1
Pages
175–179
Identifiers
DOI: 10.1016/j.bbrc.2014.01.160
Source
Elsevier
Keywords
License
Unknown

Abstract

Gastric cancer (GC) is the second common cause of cancer-related death worldwide. microRNAs (miRNAs) play important roles in the carcinogenesis of GC. Here, we found that miR-22 was significantly decreased in GC tissue samples and cell lines. Ectopic overexpression of miR-22 remarkably suppressed cell proliferation and colony formation of GC cells. Moreover, overexpression of miR-22 significantly suppressed migration and invasion of GC cells. CD151 was found to be a target of miR-22. Furthermore, overexpression of CD151 significantly attenuated the tumor suppressive effect of miR-22. Taken together, miR-22 might suppress GC cells growth and motility partially by inhibiting CD151.

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