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Total synthesis of the trisaccharide of olivomycin A

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
34
Issue
36
Identifiers
DOI: 10.1016/s0040-4039(00)73854-8

Abstract

Abstract The total synthesis of the trisaccharide of olivomycin A, which is one of the aureolic acid antitumor antibiotics, has been achieved. Our approach involves highly stereocontrolled glycosidations using 2,6-ahnydro-2-thio glycosyl donors. The 2,6-anhydro-2-thio trisaccharide 21 was constructed from 4 and 5, and then converted into the 2,6-dideoxy trisaccharide of olivomycin A 3 by hydrogenolysis and deprotection.

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