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CD137 as a biomarker for tumor-reactive T cells: finding gold in the desert.

Authors
  • Zhu, Yuwen
  • Chen, Lieping
Type
Published Article
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
Publication Date
Jan 01, 2014
Volume
20
Issue
1
Pages
3–5
Identifiers
DOI: 10.1158/1078-0432.CCR-13-2573
PMID: 24166912
Source
Medline
License
Unknown

Abstract

Although human cancer is often surrounded by immune cells, only a small number are tumor-reactive T cells that recognize the tumor antigens and are able to eliminate the cancer cells. Ye and colleagues now found that many of these tumor-reactive T cells are marked by expressing CD137, a T-cell costimulatory receptor.

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