Affordable Access

deepdyve-link
Publisher Website

CcrZ is a pneumococcal spatiotemporal cell cycle regulator that interacts with FtsZ and controls DNA replication by modulating the activity of DnaA

Authors
  • Gallay, Clement1
  • Sanselicio, Stefano1
  • Anderson, Mary E.2
  • Soh, Young Min1
  • Liu, Xue1
  • Stamsås, Gro A.3
  • Pelliciari, Simone4
  • van Raaphorst, Renske1
  • Dénéréaz, Julien1
  • Kjos, Morten3
  • Murray, Heath4
  • Gruber, Stephan1
  • Grossman, Alan D.2
  • Veening, Jan-Willem1
  • 1 University of Lausanne,
  • 2 Massachusetts Institute of Technology,
  • 3 Norwegian University of Life Sciences,
  • 4 Newcastle University,
Type
Published Article
Journal
Nature Microbiology
Publisher
Nature Publishing Group UK
Publication Date
Aug 09, 2021
Volume
6
Issue
9
Pages
1175–1187
Identifiers
DOI: 10.1038/s41564-021-00949-1
PMID: 34373624
PMCID: PMC8387234
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Unknown

Abstract

In this Article, the authors identify CcrZ as a protein that coordinates DNA replication and cell division in Streptococcus pneumoniae and other Firmicutes. CcrZ is localized to the division site by binding directly to the divisome protein FtsZ, and there it activates DnaA, the master initiator of DNA replication, through a still unknown mechanism.

Report this publication

Statistics

Seen <100 times