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The AMPA receptor antagonist NBQX does not alter the motor response induced by selective dopamine agonists in MPTP-treated monkeys

Authors
Journal
European Journal of Pharmacology
0014-2999
Publisher
Elsevier
Publication Date
Volume
235
Identifiers
DOI: 10.1016/0014-2999(93)90149-c
Keywords
  • Ampa Receptors
  • Nbqx (2
  • 3-Dihydroxy-6-Nitro-7-Sulfamoylbenzo[F]Quinoxaline(1H
  • 4H)Dione Sodium Salt)
  • Parkinsonism
  • Dyskinesia
  • Dopamine Receptor Agonists

Abstract

Abstract We studied the motor response induced by theinistration of the AMPA receptor antagonist, NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]quinoxaline (1H,4H)dione sodium salt), in two parkinsonian monkeys and its interaction with the selective D-2 dopamine receptor agonist, (+)-PHNO [(+)-4-propyl-9-hydroxynaphthoxazine], and the partial dopamine D-1 receptor agonist, CY 208–243 [(−)-4,6,6a,7,8,12b-hexahydro-7-methyl-indolo[4,3a-b]phenanthyxidine]. NBNQX treatment did not reverse the parkinsonism or change the responses previously induced by dopamine agonists. These results do not support an antiparkinsonian effect of the AMPA receptor antagonist, NBQX. In addition they indicate that there is no functional interaction between AMPA and dopamine receptors in monkeys with a substantia nigra lesion.

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