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CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation.

Authors
  • Michael Jeltsch
  • Jha, Sawan Kumar
  • Tvorogov, Denis
  • Anisimov, Andrey
  • Leppänen, Veli-Matti
  • Holopainen, Tanja
  • Kivelä, Riikka
  • Ortega, Sagrario
  • Kärpanen, Terhi
  • Alitalo, Kari
Type
Published Article
Journal
Circulation
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
May 12, 2014
Volume
129
Issue
19
Pages
1962–1971
Identifiers
DOI: 10.1161/CIRCULATIONAHA.113.002779
PMID: 24552833
Source
Medline
Keywords
License
Unknown

Abstract

These results identify A disintegrin and metalloprotease with thrombospondin motifs-3 as a VEGF-C-activating protease and reveal a novel type of regulation of a vascular growth factor by a protein that enhances its proteolytic cleavage and activation. The results suggest that CCBE1 is a potential therapeutic tool for the modulation of lymphangiogenesis and angiogenesis in a variety of diseases that involve the lymphatic system, such as lymphedema or lymphatic metastasis.

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