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Dapsone attenuates kainic acid-induced seizures in rats

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
176
Issue
1
Identifiers
DOI: 10.1016/0304-3940(94)90869-9
Keywords
  • Dapsone
  • Kainic Acid
  • Epilepsy
  • Limbic Seizure

Abstract

Abstract We tested the ability of dapsone (4,4′-diamino-diphenyl sulfone) to attenuate kainic acid-induced seizures. We observed that 9.375 and 12.5 mg/kg doses of dapsone administered 30 min before a single kainic acid (10 mg/kg) i.p. injection were able to decrease the time of electroencephalographic seizures by 52% and 82%, respectively, as compared with rats administered with 10 mg/kg kainic acid only. The 12.5 mg/kg dose of dapsone was also able to diminish both kainic acid-evoked body and head shakes (58%) and kainic acid-induced mortality (75%). These results suggest that dapsone could be used in clinical trials as anticonvulsant.

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