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Targeting cancer with peptide aptamers

Authors
Journal
Oncotarget
1949-2553
Publisher
"Impact Journals, LLC "
Publication Date
Keywords
  • Research Perspectives
Disciplines
  • Biology
  • Medicine

Abstract

A major endeavour in cancer chemotherapy is to develop agents that specifically target a biomolecule of interest. There are two main classes of targeting agents: small molecules and biologics. Among biologics (e.g.: antibodies), DNA, RNA but also peptide aptamers are relatively recent agents. Peptide aptamers are seldom described but represent attractive agents that can inhibit a growing panel of oncotargets including Heat Shock Proteins. Potential pitfalls and coming challenges towards successful clinical trials are presented such as optimizing the delivery of peptide aptamers thanks to Nanotechnology.

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