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Prolonged intravenous eptifibatide infusion for prevention of coronary stent thrombosis

Authors
Journal
International Journal of Cardiology
0167-5273
Publisher
Elsevier
Publication Date
Volume
114
Issue
3
Identifiers
DOI: 10.1016/j.ijcard.2005.11.089
Keywords
  • Stent
  • Thrombosis
  • Eptifibatide
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Coronary bare-metal stent thrombosis usually occurs within a week of angioplasty, and may result in myocardial infarction and death. Thrombosis is effectively prevented by antiplatelet therapy with aspirin and clopidogrel. We describe a patient who was unable to ingest oral medication after angioplasty due to gastrointestinal surgery, and was therefore at risk for stent thrombosis. Intravenous eptifibatide was infused for 8 days in order to achieve parentreal platelet inhibition. We suggest a role for long-term intravenous administration of glycoprotein IIb/IIIa inhibitors for prevention of stent thrombosis in patients unable to take oral antiplatelet therapy.

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