Affordable Access

Publisher Website

Anti-gliadin antibodies-56

Authors
Publisher
Elsevier B.V.
Identifiers
DOI: 10.1016/b978-044452763-9/50060-3
Disciplines
  • Biology
  • Medicine

Abstract

Publisher Summary After anti-gliadin antibodies (AGA) discovery in the 1970s, IgA- and IgG-type AGA were the only serological test able to identify patients with coeliac disease (CD) for many years. However, AGA have no longer played a significant diagnostic role since the identification of anti-endomysial and anti-transglutaminase antibodies. Gliadin peptides, which are present in foods containing wheat, barley and rye, are modified by the tissue transglutaminase enzyme (tTG) located in the extracellular space of the intestinal mucosa; conversion of glutamine residues into glutamic acid facilitates the binding of gliadin peptides to HLA antigens of class II DQ2 or DQ8 expressed on antigen-presenting cells. In individuals, with this genetic make-up, an immune response leading to the synthesis of cytokines and specific anti-tTG and AGA antibodies can be triggered. AGA are determined by enzyme-linked immunosorbent assay (ELISA). The AGA IgA and IgG tests that use purified gluten extracts are unsatisfactory, and the different methods are not comparable. The recent identification of immunodominant gliadin epitopes are able to trigger a specific T-cell response in CD patients enabled to far more specific and sensitive AGA tests to be devised. AGA determination can be useful in patients under 5 years old; in their case, it is useful to perform this test in association with anti-tTG IgA. Positivity for AGA IgG can also be important in patients with an IgA deficiency, in whom it may be the only positive serological marker in association with anti-tTG IgG.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Anti-gliadin antibodies.

on Journal of Pediatric Gastroent... February 1991

[Antigenicity of gliadin and antibodies against gl...

on Acta paediatrica Academiae Sci... 1975

The stability of anti-lipoidal antibodies to heat...

on Acta Pathologica Microbiologic... 1961
More articles like this..