Abstract Although many pharmacists and other health care providers are extremely bright, well-educated, and highly motivated, most do not receive the training they need to be confident and persuasive speakers. In today's competitive job market, pharmacists must be able to communicate not only with those in their field of expertise but also with others, including patients, corporate leaders, and budget directors. This short article is based on years of training pharmacists, physicians, and other health care providers to become better speakers and communicators. It describes the most common mistakes speakers make and the best ways to correct those mistakes. Those mistakes include: (1) trying to tell too much, (2) not meeting the needs of the specific audience, (3) not having a clear purpose, (4) lacking clear organization, (5) speaking with a monotonous voice, (6) reading the talk without practicing, and (7) using poorly designed visual aids. Having worked with thousands of scientists and health care providers, I have found that with training and practice they can—and often do—become more effective and dynamic presenters and communicators.