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Antiviral Drug Resistance: Mechanisms and Clinical Implications

Authors
Journal
Infectious Disease Clinics of North America
0891-5520
Publisher
Elsevier
Publication Date
Volume
24
Issue
2
Identifiers
DOI: 10.1016/j.idc.2010.01.001
Keywords
  • Drug Resistance
  • Transplant
  • Cytomegalovirus
  • Herpes Simplex Virus
  • Varicella Zoster Virus
  • Hepatitis B Virus
Disciplines
  • Medicine

Abstract

Antiviral drug resistance is an increasing concern in immunocompromised patient populations, where ongoing viral replication and prolonged drug exposure lead to the selection of resistant strains. Rapid diagnosis of resistance can be made by associating characteristic viral mutations with resistance to various drugs as determined by phenotypic assays. Management of drug resistance includes optimization of host factors and drug delivery, selection of alternative therapies based on knowledge of mechanisms of resistance, and the development of new antivirals. This article discusses drug resistance in herpesviruses and hepatitis B.

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