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Cerebrovascular amyloid in scrapie-affected sheep reacts with antibodies to prion protein

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
92
Issue
2
Identifiers
DOI: 10.1016/0304-3940(88)90067-5
Keywords
  • Cerebrovascular Amyloid
  • Scrapie
  • Sheep
  • Prion Protein
  • β-Protein
  • Antibody
Disciplines
  • Biology
  • Chemistry
  • Medicine

Abstract

Abstract In an immunohistochemical study of naturally-occurring and experimental scrapie in sheep, deposits of cerebrovascular amyloid were found to react with antibodies to hamster scrapie prion protein (PrP 27–30), but not with antibodies to the amyloid β-protein of Alzheimer's disease. It is concluded that this vascular amyloid is formed from PrP and is therefore closely associated with scrapie infection. It is likely that this amyloid is formed from a host precursor protein as a specific pathological consequence of invasion by the scrapie agent.

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