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Nerve growth factor produces a temporary facilitation of recovery from entorhinal cortex lesions

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
261
Issue
1
Identifiers
DOI: 10.1016/0006-8993(83)91291-x
Keywords
  • Nerve Growth Factor
  • Brain Damage
  • Recovery Of Function
  • Entorhinal Cortex

Abstract

Abstract Mature rats with entorhinal cortex lesions are impaired on learning a series of complex maze problems. A single, bilateral injection of NGF into the dorsal hippocampus caused an improvement during the initial maze learning, but it did not result in permanent recovery from the effects of the brain lesions. It is possible that chronic administration of NGF may have conferred more long-lasting functional recovery.

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