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Secondary leukemia with a translocation (8;21)?

Authors
Journal
Cancer Genetics and Cytogenetics
0165-4608
Publisher
Elsevier
Publication Date
Volume
31
Issue
2
Identifiers
DOI: 10.1016/0165-4608(88)90227-0
Disciplines
  • Medicine

Abstract

Abstract The clinical features and cytogenetic changes of acute myeloid leukemia (AML) developing 10 years after radiotherapy and chemotherapy (for osteosarcoma) are described. Features of both de novo AML (FAB M2 morphology, t(8;21), and “secondary leukemia” (additional cytogenetic changes, resistance to chemotherapy) were present. The importance of differentiation between primary and “therapy-linked” disease, and the difficulties in making such a distinction, are discussed.

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