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Synthesis, in vitro antimicrobial and cytotoxic activities of novel pyrimidine–benzimidazol combinations

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
24
Issue
12
Identifiers
DOI: 10.1016/j.bmcl.2014.04.037
Keywords
  • Pyrimidine
  • Benzimidazole
  • Synthesis
  • Antimicrobial
  • Cytotoxic Activities
Disciplines
  • Design

Abstract

Abstract A series of novel 4-substituted-2-{[(1H-benzo[d]imidazol-2-yl)methyl] thio}-6-methylpyrimidine derivatives were designed, synthesized and evaluated for their cytotoxic activities against four human cancer cell lines and inhibitory activities against five type culture strains in vitro. Some of synthetic pyrimidine–benzimidazol combinations showed good inhibitory activities against Stenotrophomonas maltophilia, especially compounds 7b and 7c. Compounds 7a and 7d exhibited enhanced activities against MGC-803 in vitro, when compared to 5-Fu.

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