Affordable Access

Publisher Website

Preparation and surface properties of polyrotaxane-containing tri-block copolymers as a design for dynamic biomaterials surfaces

Authors
Journal
Colloids and Surfaces B Biointerfaces
0927-7765
Publisher
Elsevier
Publication Date
Volume
89
Identifiers
DOI: 10.1016/j.colsurfb.2011.09.020
Keywords
  • Polyrotaxane Tri-Block Copolymer
  • Dynamic Contact Angle
  • Quartz Crystal Microbalance With Dissipation
  • Molecular Mobility
  • Protein Adsorption
Disciplines
  • Biology

Abstract

Abstract A tri-block copolymer series containing hydrophilic polyrotaxane and hydrophobic poly(iso-butylmethacrylate) (PiBMA) segments was prepared by atom transfer radical polymerization (ATRP), starting from a pseudopolyrotaxane consisting of 2-bromoisobutyryl end-capped poly(ethylene glycol) (PEG) and α-cyclodextrin (α-CD) and followed by methylation. The dynamic wettability and molecular mobility of the copolymer surfaces were evaluated by dynamic contact angle (DCA) and quartz crystal microbalance with dissipation (QCM-D) measurements, respectively. The polyrotaxane tri-block copolymer surfaces were found to show pronounced dynamic wettability and molecular mobility compared to the control surfaces-a tri-block polymer consisting of PEG and PiBMA, and a PiBMA homopolymer-suggesting that a polyrotaxane loop-like structure exists at the outermost surface in an aqueous environment and exhibits dynamic properties attributable to the possible mobile nature of hydrated α-CD molecules along the PEG backbone. Finally, excellent protein adsorption repellency was achieved on the polyrotaxane tri-block copolymer surface, presumably due to the mobile nature of the supramolecular architecture on the surface.

There are no comments yet on this publication. Be the first to share your thoughts.