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Caveolin-1 exists and may function in cardiomyocytes.

Authors
  • 1
  • 1 Department of Pharmacology, Medical Sciences Building, University of Alberta, Edmonton, AB T6G2H7, Canada. , (Canada)
Type
Published Article
Journal
Canadian Journal of Physiology and Pharmacology
1205-7541
Publisher
Canadian Science Publishing
Publication Date
Volume
88
Issue
1
Pages
73–76
Identifiers
DOI: 10.1139/Y09-114
PMID: 20130741
Source
Medline
License
Unknown

Abstract

Whether ventricular cardiac myocytes of mouse contain caveolin-1 is disputed. It has been claimed to be exclusively in nearby endothelial cell profiles. Recently, matrix metalloproteinase-2 (MMP-2) was reported to be present in mouse ventricular cardiac myocytes, colocalized with caveolin-1, and caveolin-1 knockout was found to cause the loss of MMP-2 from mouse ventricular cardiac myocytes and affect their functioning. To resolve this dispute, we labeled cardiac myocytes with caveolin-1 and endothelial cells with caveolin-2. Caveolin-2 is agreed to be present exclusively in endothelial cells. The results showed that mouse ventricular myocytes were labeled with caveolin-1 antibodies independently of any caveolin-2 labeling, and endothelial cells were labeled with both caveolin-1 and caveolin-2 antibodies. This confirms that caveolin-1 is present in mouse ventricular cardiac myocytes as well as endothelial cells. Previous evidence confirms that loss of caveolin-1 affects the function of mouse ventricular cardiac myocytes and suggests that MMP-2 may be involved.

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