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Cation complexed DNA. A novel class of immunoadsorbents for anti-DNA antibodies.

Authors
  • DeBari, V A
  • Needle, M A
Type
Published Article
Journal
Journal of Immunological Methods
Publisher
Elsevier
Publication Date
Jan 01, 1981
Volume
40
Issue
1
Pages
89–94
Identifiers
PMID: 6970783
Source
Medline
License
Unknown

Abstract

DNA can be precipitated as complexes with metal and organic cations. We have prepared these products using divalent metal cations (Cu2+, Mn2+, Ni2+, Zn2+, and Co2+) and ditetrazolium ions (blue tetrazolium and neotetrazolium). They are effective adsorbents, in vitro, for anti-nDNA antibodies and in reducing the titer of antinuclear antibodies in the sera from patients with autoimmune disease. They selectively adsorb most of the antinuclear components from a mixture of antimitochondrial and antinuclear antibodies.

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