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Cathepsin D gene exon 2 polymorphism and sporadic Alzheimer's disease.

Authors
  • McIlroy, S P
  • Dynan, K B
  • McGleenon, B M
  • Lawson, J T
  • Passmore, A P
Type
Published Article
Journal
Neuroscience Letters
Publisher
Elsevier
Publication Date
Oct 01, 1999
Volume
273
Issue
2
Pages
140–141
Identifiers
PMID: 10505636
Source
Medline
License
Unknown

Abstract

It has recently been reported that a genetic polymorphism in exon 2 of the cathepsin D gene conferred increased risk for development of Alzheimer's disease (AD). Because of the potential importance of this report we tested this association in a clinically well-defined group of AD patients and age and sex matched control subjects from the relatively genetically homogeneous Northern Ireland population. This study failed to confirm the reported association between the cathepsin D exon 2 polymorphism and AD. We conclude that if an association exists between this polymorphism and AD it is likely to be small.

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