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Catestatin Regulates Epithelial Cell Dynamics to Improve Intestinal Inflammation

Authors
  • eissa, nour
  • hussein, hayam
  • mesgna, ruth
  • bonin, sandra
  • hendy, geoffrey n.
  • metz-boutigue, marie-hélène
  • bernstein, charles n.
  • ghia, jean-eric
Publication Date
Sep 20, 2018
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

DSS-induced Caco2 cell epithelial injury, and the presence of STAT-3 inhibitor abolished the beneficial effect of CST. In inflammatory conditions, we conclude that CST could regulate intestinal mucosal dynamic via a potential STAT3-dependent pathway that needs to be further defined. Targeting CST in intestinal epithelial cells (IECs) should be a promising therapeutic approach such as when intestinal epithelial cell homeostasis is compromised in UC patients.

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