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Caspofungin-resistant Candida tropicalis strains causing breakthrough fungemia in patients at high risk for hematologic malignancies.

Authors
  • Garcia-Effron, Guillermo
  • Kontoyiannis, Dimitrios P
  • Lewis, Russell E
  • Perlin, David S
Type
Published Article
Journal
Antimicrobial Agents and Chemotherapy
Publisher
American Society for Microbiology
Publication Date
Nov 01, 2008
Volume
52
Issue
11
Pages
4181–4183
Identifiers
DOI: 10.1128/AAC.00802-08
PMID: 18794386
Source
Medline
License
Unknown

Abstract

We identified three cases of C. tropicalis strains causing breakthrough fungemia in allogeneic stem cell recipients receiving caspofungin prophylaxis and treatment. Three genetically unrelated isolates with high echinocandin MICs were identified. Each strain carried a characteristic mutation conferring an amino acid substitution within Fks1p hot spot 1.

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