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Caspase-3 and its inhibitor Ac-DEVD-CHO in rat lens epithelial cell apoptosis induced by hydrogen in vitro.

Authors
  • Yao, Ke
  • Wang, Kaijun
  • Xu, Wen
  • Sun, Zhaohui
  • Shentu, Xingchao
  • Qiu, Peijin
Type
Published Article
Journal
Chinese medical journal
Publication Date
Jul 01, 2003
Volume
116
Issue
7
Pages
1034–1038
Identifiers
PMID: 12890378
Source
Medline
License
Unknown

Abstract

The activation of caspase-3 plays an important role in executing apoptosis in H(2)O(2)-treated lens epithelial cells and in the formation of cataract. The caspase-3 inhibitor Ac-DEVD-CHO may effectively prevent lens epithelial cell apoptosis caused by oxidative injury.

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