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Case-Control Study to Investigate the Association Between Serum Apolipoprotein B/A1 Ratio and Atrial Fibrillation by Sex in 920 Patients from China

  • Zhong, Xia1
  • Jiao, Huachen2
  • Zhao, Dongsheng1
  • Teng, Jing1
  • Yang, Mengqi1
  • 1 The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, PR China
  • 2 Department of Cardiology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, PR China
Published Article
Medical Science Monitor
"International Scientific Information, Inc."
Publication Date
May 14, 2022
DOI: 10.12659/MSM.936425
PMID: 35567295
PMCID: PMC9116146
PubMed Central
  • Clinical Research


Background The serum apolipoprotein B/A1 ratio (APOB/APOA1) has been shown to predict cardiovascular events, whereas the effect of the APOB/APOA1 ratio on atrial fibrillation (AF) is less known. We investigated the association between the APOB/APOA1 ratio and AF by sex in 920 patients from China. Material/Methods We reviewed clinical data on 1840 hospitalized patients, including 920 patients with AF (male/female: 460/460, age: 68.62±10.36 years) and 920 age- and sex-matched patients without AF with sinus rhythm in China between January 2019 and September 2021. Pearson correlation analysis was performed to investigate the correlation between APOB/APOA1 ratio and AF-related metabolic factors. Logistic regression analysis was used to determine the odds ratios (ORs) and 95% confidence intervals (CIs). Results Low serum APOB/APOA1 ratios in male and female patients were significantly associated with AF after adjusting for confounding factors (OR 0.159, 95% CI 0.058–0.432, P <0.05). Serum APOB/APOA1 ratio was positively correlated with triglyceride (TG) (r=0.146, P <0.05) and total cholesterol (TC) (r=0.227, P <0.05) and was negatively correlated with albumin (ALB) (r=−0.128, P <0.05) and prealbumin (PAB) (r=−0.107, P <0.05). There was no significant difference of APOB/APOA1 ratio in different subtypes, complications, and statin use in patients with AF ( P >0.05). Conclusions A low serum APOB/APOA1 ratio in male and female patients from China was significantly related to AF. This finding implies that a low serum APOB/APOA1 ratio may be associated with the causes of AF. Further studies are needed to determine causalities.

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