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A Case-Control Analysis of the Impact of Venous Thromboembolic Disease on Quality of Life of Patients with Cancer: Quality of Life in Cancer (Qca) Study

Authors
  • Marin-Barrera, Lucia1
  • Muñoz-Martin, Andres J.2
  • Rios-Herranz, Eduardo
  • Garcia-Escobar, Ignacio
  • Beato, Carmen
  • Font, Carme
  • Oncala-Sibajas, Estefania
  • Revuelta-Rodriguez, Alfonso
  • Areses, Maria Carmen
  • Rivas-Jimenez, Victor
  • Moreno-Santos, Maria Angeles
  • Ballaz-Quincoces, Aitor3
  • Lopez-Saez, Juan-Bosco
  • Gallego, Iria2
  • Elias-Hernandez, Teresa1
  • Asensio-Cruz, Maria Isabel1
  • Chasco-Eguilaz, Leyre3
  • Garcia-Gonzalez, Gonzalo2
  • Estevez-Garcia, Purificacion
  • Otero, Remedios1
  • And 2 more
  • 1 (R.O.)
  • 2 (G.G.-G.)
  • 3 (L.C.-E.)
Type
Published Article
Journal
Cancers
Publisher
MDPI AG
Publication Date
Dec 26, 2019
Volume
12
Issue
1
Identifiers
DOI: 10.3390/cancers12010075
PMID: 31888065
PMCID: PMC7017186
Source
PubMed Central
Keywords
License
Green

Abstract

Although there is published research on the impact of venous thromboembolism (VTE) on quality of life (QoL), this issue has not been thoroughly investigated in patients with cancer—particularly using specific questionnaires. We aimed to examine the impact of acute symptomatic VTE on QoL of patients with malignancies. This was a multicenter, prospective, case-control study conducted in patients with cancer either with (cases) or without (controls) acute symptomatic VTE. Participants completed the EORTC QLQ-C30, EQ-5D-3L, PEmb-QoL, and VEINES-QOL/Sym questionnaires. Statistically significant and clinically relevant differences in terms of global health status were examined. Between 2015 and 2018, we enrolled 425 patients (128 cases and 297 controls; mean age: 60.2 ± 18.4 years). The most common malignancies were gastrointestinal (23.5%) and lung (19.8%) tumors. We found minimally important differences in global health status on the EQ-5D-3L (cases versus controls: 0.55 versus 0.77; mean difference: −0.22) and EORTC QLQ-C30 (47.7 versus 58.4; mean difference: −10.3) questionnaires. There were minimally important differences on the PEmb-QoL questionnaire (44.4 versus 23; mean difference: −21.4) and a significantly worse QoL on the VEINES-QOL/Sym questionnaire (42.7 versus 51.7; mean difference: −9). In conclusion, we showed that acute symptomatic VTE adversely affects the QoL of patients with malignancies.

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