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[A case of subependymal giant cell astrocytoma not associated with tuberous sclerosis].

Authors
  • 1
  • 1 Department of Neurosurgery, Hiroshima City Asa Hospital, 2-1-1 Kabe-minami, Kita-ku, Asa, Hiroshima-city, Hiroshima 731-0293, Japan. , (Japan)
Type
Published Article
Journal
No shinkei geka. Neurological surgery
Publication Date
Volume
31
Issue
5
Pages
543–548
Identifiers
PMID: 12755028
Source
Medline
License
Unknown

Abstract

The authors present a case of a subependymal giant cell astrocytoma (SGCA) not associated with tuberous sclerosis. On admission, a six-year-old boy had obstructive hydrocephalus caused by a huge intraventricular tumor. Preoperative T1-weighted MR images with gadolinium showed heterogeneous enhancement of the lesion. The tumor was totally removed through a right transcortical approach with frontal craniotomy. Immunohistochemical staining for glial fibrillary acidic protein (GFAP) showed a positive reaction in some of the large tumor cells and the labeling index of MIB-1 was < 1.0%. Histological examinations revealed SGCA. He has no other evidence of tuberous sclerosis at present, but the patient in this case is an infant, so there is a possibility of his being diagnosed as tuberous sclerosis in the future. Therefore, systemic regular follow-up is recommended, even when his condition is asymptomatic.

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