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Case report of familial COVID-19 cluster associated with High prevalence of anosmia, ageusia, and gastrointestinal symptoms

Authors
  • Ho, Bethany E.1
  • Ho, Andrea P.1
  • Ho, Michaela A.2
  • Ho, Elizabeth C.3
  • 1 University of Colorado School of Medicine, 13001 E. 17th Pl, Aurora, CO 80045, USA
  • 2 Colorado State University, Department of Biology, 251 W. Pitkin St, Fort Collins, CO 80521, USA
  • 3 Colorado College, Department of Biology, 14 E, W Cache La Poudre St, Colorado Springs, CO 80903, USA
Type
Published Article
Journal
IDCases
Publisher
Elsevier
Publication Date
Oct 01, 2020
Volume
22
Identifiers
DOI: 10.1016/j.idcr.2020.e00975
PMID: 33024695
PMCID: PMC7528941
Source
PubMed Central
Keywords
License
Unknown

Abstract

Background Patients with COVID-19 most commonly report respiratory symptoms, with a minority reporting gastrointestinal (GI) symptoms in currently available reports. Additionally, little is known about the symptoms of anosmia/hyposmia, ageusia, and dysgeusia anecdotally seen in COVID-19 patients, which may potentially be considered both GI and sensory/neurological manifestations of infection. We hope to clarify the prevalence of these symptoms and patterns of transmission within a family cluster. Case presentation We interviewed 7 patients via oral inquiries and a questionnaire, collecting data on subject symptoms and their durations. Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to confirm 2 of these cases. We report a familial cluster of 5 presumed and 2 confirmed COVID-19 cases, all of whom reported one or more GI symptoms and 5 of whom reported sensory symptoms of anosmia/hyposmia, ageusia/hypogeusia, and/or dysgeusia. Conclusions This frequency of GI symptoms is high relative to currently available epidemiological reports, which also infrequently report on sensory symptoms. COVID-19 exhibits wide variation in duration, severity, and progression of symptoms, even within a familial cluster.

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