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A case of prostatic adenocarcinoma with Paneth cell-like appearance.

Authors
  • Nakamura, Yasuhiro
  • Fujishima, Fumiyoshi
  • Watanabe, Mika
  • Taniuchi, Shinji
  • Ishida, Kazuyuki
  • Ishidoya, Shigeto
  • Arai, Yoichi
  • Sasano, Hironobu
Type
Published Article
Journal
Polish journal of pathology : official journal of the Polish Society of Pathologists
Publication Date
Jan 01, 2011
Volume
62
Issue
1
Pages
60–64
Identifiers
PMID: 21574107
Source
Medline
License
Unknown

Abstract

Paneth cell-like appearance of prostatic carcinoma cells with eosinophilic cytoplasmic granules is rarely reported, and is known to be associated with neuroendocrine differentiation of carcinoma cells. We report a case of prostatic adenocarcinoma with Paneth cell-like appearance that was localized next to conventional adenocarcinoma, and demonstrate its neuroendocrine differentiation by using immunohistochemical analysis. Paneth cell-like appearance of prostatic carcinoma cells should be recognized and considered as a sign of neuroendocrine differentiation due to the possible association with resistance to hormone therapy.

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