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A Case of Paraneoplastic Myoclonus Attributed to Non-Small Cell Lung Cancer.

Authors
  • Nichols, Jennifer L1
  • Lee, Brett J1
  • Chung, Kathryn A1
  • 1 Oregon Health and Science University (OHSU) and the VA Portland Health Care System, US.
Type
Published Article
Journal
Tremor and other hyperkinetic movements (New York, N.Y.)
Publication Date
Jun 16, 2020
Volume
10
Pages
7–7
Identifiers
DOI: 10.5334/tohm.42
PMID: 32775021
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

It is well known that myoclonus can be a paraneoplastic manifestation of underlying malignancy. A 78-year-old male diagnosed with papillary variant non-small cell lung cancer (NSCLC) presented with tremulousness that rapidly evolved into severe, diffuse myoclonus with prominent palatal involvement requiring intubation. The generalized myoclonus resolved with on levetiracetam, chemotherapy and immune modulation. While low titer positive P/Q type calcium channel autoantibodies were detected, it's etiologic relevance is unclear. This case highlights a rare neurologic paraneoplastic presentation of papillary NSCLC. It also illustrates the importance of monitoring airway safety when myoclonus is generalized. A new, rare paraneoplastic presentation of papillary variant non-small cell lung adenocarcinoma is described. The patient presented with severe diffuse myoclonus with prominent palatal involvement without encephalitis that responded to a combination of chemotherapy, immune modulation, and levetiracetam. No clear causal antibody was found. Copyright: © 2020 The Author(s).

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