Affordable Access

A case of neurofibrosarcoma associated with neurofibromatosis--ganglioside analysis.

Authors
  • Morioka, N
  • Tsuchida, T
  • Ishibashi, Y
  • Otsuka, F
Type
Published Article
Journal
Clinical and Experimental Dermatology
Publisher
Wiley
Publication Date
Nov 01, 1991
Volume
16
Issue
6
Pages
467–470
Identifiers
PMID: 1806326
Source
Medline
License
Unknown

Abstract

A patient with neurofibromatosis developed neurofibrosarcoma (NFS). The tumour was composed of spindle-shaped cells with atypical nuclei arranged in a fascicular or sheet-like fashion. The tumour cells had discontinuous basement membrane-like structures and were positively stained with the monoclonal antibody against S100 protein alpha chain. Both the primary tumour and its cultured cells contained GM3 and GD3 as major gangliosides. The ganglioside pattern of the primary tumour corresponds to that of NFS in our previous study. In the cultured NFS cells, the relative amount ratio of GM3 to GD3 is almost reversed compared to that of the primary tumour. This reversion may reflect some environmental influence on the ganglioside metabolism of NFS.

Report this publication

Statistics

Seen <100 times