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A case of acebutolol intoxication.

Authors
  • Sangster, B
  • de Wildt, D
  • van Dijk, A
  • Klein, S
Type
Published Article
Journal
Journal of toxicology. Clinical toxicology
Publication Date
Mar 01, 1983
Volume
20
Issue
1
Pages
69–77
Identifiers
PMID: 6887301
Source
Medline
License
Unknown

Abstract

A case of a nonfatal acebutolol intoxication in a 15 year old female is described. Ingestion of 7600 mg acebutolol resulted in a plasma acebutolol concentration of 15 mg/1 one hour after ingestion. The patient remained conscious, had a severe hypotension and the electrocardiogram showed a 1st degree AV-block and severe intraventricular conduction disturbances at a rate of 70 bpm. After the administration of calcium gluconate and plasma the blood pressure gradually increased to normal values in 2 hours time. Plasma halflife of acebutolol was 8 hours. Pathophysiology of acebutolol intoxication is discussed.

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