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Cas3 Protein—A Review of a Multi-Tasking Machine

Authors
  • He, Liu1
  • St. John James, Michael1
  • Radovcic, Marin
  • Ivancic-Bace, Ivana
  • Bolt, Edward L.1
  • 1 (M.S.J.J.)
Type
Published Article
Journal
Genes
Publisher
MDPI AG
Publication Date
Feb 18, 2020
Volume
11
Issue
2
Identifiers
DOI: 10.3390/genes11020208
PMID: 32085454
PMCID: PMC7074321
Source
PubMed Central
Keywords
License
Green

Abstract

Cas3 has essential functions in CRISPR immunity but its other activities and roles, in vitro and in cells, are less widely known. We offer a concise review of the latest understanding and questions arising from studies of Cas3 mechanism during CRISPR immunity, and highlight recent attempts at using Cas3 for genetic editing. We then spotlight involvement of Cas3 in other aspects of cell biology, for which understanding is lacking—these focus on CRISPR systems as regulators of cellular processes in addition to defense against mobile genetic elements.

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