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Carvedilol for primary prophylaxis of variceal bleeding in cirrhotic patients with haemodynamic non-response to propranolol.

Authors
  • Reiberger, Thomas
  • Ulbrich, Gregor
  • Ferlitsch, Arnulf
  • Payer, Berit Anna
  • Schwabl, Philipp
  • Pinter, Matthias
  • Heinisch, Birgit B
  • Trauner, Michael
  • Kramer, Ludwig
  • Peck-Radosavljevic, Markus
Type
Published Article
Journal
Gut
Publisher
BMJ
Publication Date
Nov 01, 2013
Volume
62
Issue
11
Pages
1634–1641
Identifiers
DOI: 10.1136/gutjnl-2012-304038
PMID: 23250049
Source
Medline
Keywords
License
Unknown

Abstract

Carvedilol leads to a significantly greater decrease in HVPG than propranolol. Using carvedilol for primary prophylaxis a substantial proportion of non-responders to propranolol can achieve a haemodynamic response, which is associated with improved outcome with regard to prevention of variceal bleeding, hepatic decompensation and death.

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