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Carvedilol for primary prophylaxis of variceal bleeding in cirrhotic patients with haemodynamic non-response to propranolol.

Authors
Type
Published Article
Journal
Gut
1468-3288
Publisher
BMJ
Publication Date
Volume
62
Issue
11
Pages
1634–1641
Identifiers
DOI: 10.1136/gutjnl-2012-304038
PMID: 23250049
Source
Medline
Keywords
License
Unknown

Abstract

Carvedilol leads to a significantly greater decrease in HVPG than propranolol. Using carvedilol for primary prophylaxis a substantial proportion of non-responders to propranolol can achieve a haemodynamic response, which is associated with improved outcome with regard to prevention of variceal bleeding, hepatic decompensation and death.

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