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CARs need a jump start to get going

Authors
  • Lillemeier, Björn F.1
  • 1 Nomis Center for Immunobiology and Microbial Pathogenesis & Waitt Advanced Biophotonics Center, Salk Institute for Biological Studies, La Jolla, CA, USA , La Jolla (United States)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Jul 06, 2020
Volume
21
Issue
8
Pages
823–824
Identifiers
DOI: 10.1038/s41590-020-0735-0
Source
Springer Nature
License
Yellow

Abstract

CAR T cells are engineered to recognize tumor-specific antigens and kill tumor cells. A study of CAR T cell activation using single-molecule microscopy reveals that CARs fail to efficiently convert antigen binding into early T cell signaling events.

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